thrombokinase

The conversion of thrombogen into prothrombin has been proved to be due to the action of a second ferment which has been named thrombokinase, and this latter is again absent from living blood.

The plasma collected from such blood is found to contain thrombogen but no thrombokinase.

If plasma containing thrombogen but no thrombokinase be treated with a saline extract of any tissues it will soon clot.

It is apparently the actual contact which initiates these changes, changes which are fundamentally chemical in character, resulting in the production of thrombokinase and possibly also of thrombogen.