Retin-A

Kligman, who would go on to pioneer the acne and wrinkle treatment Retin-A, died in 2010.

“I have a picture from my sophomore dance in high school where my skin is literally falling off my face from using too much Retin-A to treat my acne,” because he wasn’t given the right information, he said.

This led to tretinoin’s approval by the Food and Drug Administration in 1971, subsequently marketed under the brand name Retin-A.

Skin-care brands have developed a new generation of high-strength retinoids in the past few years that are intended to be more easily tolerated by the skin because of the addition of hydrating ingredients to the formulas, such as RoC Retinol, a line that includes creams and serums; Medik8 Crystal Retinal, sold in four different strengths, so users can slowly titrate up; and Altreno, a prescription medicine from the makers of Retin-A.

You must consider the Holmesburg Prison Experiment, where the doctor who created a popular skin cream called Retin-A conducted a series of experiments, biopsies and painful procedures on inmates without disclosing the dangers.