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major histocompatibility complex

noun

Immunology.
  1. MHC.


major histocompatibility complex

noun

  1. the full name for MHC
“Collins English Dictionary — Complete & Unabridged” 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

major histocompatibility complex

  1. A group of genes that code for cell-surface histocompatibility antigens and are the principal determinants of tissue type and transplant compatibility. They are the most diverse genes in humans and are used to determine if a sample of DNA comes from a specific person.
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Example Sentences

Examples have not been reviewed.

Researchers believe that a particular group of genes, the major histocompatibility complex, play a large role in scent production.

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Approximately 65% of elite controllers carry a particular variant of the human leukocyte antigen B gene, which is located in the major histocompatibility complex region, a part of our DNA that controls the adaptive immune response to pathogens and other threats.

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Doherty won the Nobel Prize for medicine in 1996 with his Swiss colleague Rolf Zinkernagel for “their discoveries concerning the specificity of the cell-mediated immune defence and the biological role of the major histocompatibility complex”.

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One possibility is to use gene editing to remove the markers on transplanted cells, called the major histocompatibility complex, that red-flag them for the host’s immune system.

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A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells.

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