genome

The dire wolf genome likely differs from that of the gray wolf in millions or tens of millions of ways.

With that ancient DNA, scientists identified gene variants specific to dire wolves and then performed multiplex gene editing with a genome from the gray wolf, dire wolves’ closest living relatives.

"Colossal compared the genomes of the dire wolf and the grey wolf, and from about 19,000 genes, they determined that 20 changes in 14 genes gave them a dire wolf."

Her subject was Arabidopsis thaliana, a mustard also known as mouse-ear cress, that has been described as a model plant for genome gnalysis.

“We know that ANKLE2 is important for virus replication and that if we remove ANKLE2 from cells artificially using genome editing, we can reduce virus replication,” Shah said.