catastrophic

Women have two X chromosomes, while males have X and Y, meaning the appearance of the gene can be more catastrophic in male pregnancies.

That would be "catastrophic for our business," Le says.

Calling this a constitutional crisis undersells the catastrophic implications of the emergency.

Isaiah suffered "catastrophic" brain damage after being deprived of oxygen at birth and died in March 2018.

It was against that backdrop Onana made a catastrophic mistake for Lyon's opening goal in the 2-2 draw, then erred for the injury-time equaliser, the negativity for that heightened massively by the first inexplicable blunder.